My 7-Day Review of QMS Medicosmetics’ Night Collagen Serum

Is QMS Medicosmetics' Night Collagen Serum the nightly miracle? I put it to the test.
Updated on: April 1, 2025

Image courtesy of QMS Medicosmetics

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QMS Medicosmetics may not be the biggest name in skincare, but it’s certainly worth paying attention to, especially when they introduce something like their Night Collagen Serum. According to the brand, this overnight treatment is designed to help skin look brighter and more refreshed by morning, with technologies like Matrixyl 3000®, Neotec A15® Collagen, and a touch of hyaluronic acid working to keep skin hydrated and smooth. After a full week of testing, I’ve gathered enough insight to decide if it’s truly worth the price tag.

Disclaimer: This review isn’t paid or sponsored in any way. Everything here reflects my own experiences and personal opinions. As with any skincare product, individual results may vary, so it’s always best to keep that in mind before adding something new to your routine.

What Is Night Collagen Serum?

This particular serum from QMS Medicosmetics is designed for overnight use, placing it in the same category as a typical night cream. In general, night treatments are known for working on the skin while you sleep, when the skin’s natural rejuvenation process is in full swing. They often include ingredients that encourage hydration, support a smoother look, and help address various signs of aging.

With this product, the focus is on collagen-based technology, specifically, the brand’s Neotec A15® Collagen, which aims to support the skin’s appearance by helping it feel firmer and more refined come morning. Matrixyl 3000® is also included, a commonly referenced peptide blend mainstreamed in some skincare formulas to address fine lines. Rounding out the blend is hyaluronic acid, which seeks to lock in moisture and further hydrate the skin overnight. The serum has a lightweight texture intended to absorb easily, so it fits well into a nighttime routine without feeling overly heavy or greasy.

Did It Work?

In the spirit of being “very scientific,” I paused my usual night cream for a few days and used only the Night Collagen Serum before going to bed. From day one, I noticed the serum’s lightweight consistency made my evening routine feel a bit more fuss-free than usual, which was a welcome change. After the first night, my skin felt fairly soft and well-hydrated in the morning, though not dramatically different from my normal results.

As the week went on, I really honed in on the serum’s hydrating aspect. My skin seemed to maintain a nice, supple feel, and while I didn’t see any miraculous transformation in terms of firmness, I couldn’t deny a subtle plumpness each day. Fine lines around my forehead and cheeks looked slightly less pronounced in the mornings, which was a pleasant surprise. However, by the end of the 7-day test, I realized that the improvements felt modest rather than game-changing.

So, did it live up to its claims? It certainly delivered on hydration and a gentle improvement in skin texture, making it a decent option for those seeking a more refreshed look by morning. But for me personally, the subtle results weren’t enough to fully justify switching out my go-to night cream long-term. I’d give it credit for making my skin look a bit more awake, but I won’t likely add it to my permanent collection.

Night Collagen Serum’s Main Ingredients Explained

Central to this product’s formula are a few standout components that work together to give skin a targeted overnight boost. Matrixyl 3000®, a peptide with a reputation for helping reduce fine lines, serves as one of the serum’s main attractions, while the brand’s Neotec A15® Collagen aims to support a more refined, firm-looking complexion. If you’re familiar with collagen-based skincare, you’ll recognize that peptides and collagen fragments can both help visibly smooth the skin’s surface, making them popular in many anti-aging products. Hyaluronic acid is also at play here, delivering a hefty dose of moisture retention to maintain hydration levels. On top of that, Eperua Falcata Bark Extract and Bis (Tripeptide-1) Copper Acetate round out the blend, working quietly to reinforce the skin’s appearance for a subtle improvement over time.

Beyond these heavy hitters, the formula includes glycerin and other humectants to support a soft, balanced feel, plus ingredients like bisabolol and Panthenol (vitamin B5) that are typically known for their soothing properties. With that said, it’s worth mentioning that the presence of lactose and whey protein means this product isn’t vegan-friendly, though it may still fit within some vegetarian guidelines. As for clogging pores: none of the listed ingredients are commonly known to be comedogenic (in other words, likely to block pores and cause breakouts), but sensitive or acne-prone skin types should still spot-test before diving in. Fans of gentle, moisture-rich night formulas should appreciate the well-rounded approach of this ingredient lineup.

What I Liked/Didn’t Like

After several nights of testing, here’s a straightforward look at where this product excels and where it may come up short.

What Works Well:

  • Lightweight texture makes it easy to layer without feeling heavy.
  • Offers a gentle plumping effect, which subtly softens the look of fine lines.
  • Hydrates well overnight, so skin feels comfortable by morning.
  • Includes fragrance (parfum), but it’s not overwhelming.

What to Consider:

  • Those seeking dramatic or fast changes in skin firmness might find the results too subtle.
  • Price could be a factor for anyone watching their budget.
  • Contains lactose and whey protein, which may not align with all dietary preferences.
  • The level of improvement may not fully replace a favorite night cream for everyone.

My Final Thoughts

While I can appreciate QMS Medicosmetics aiming high with their Night Collagen Serum, I wouldn’t say it entirely blew me away. It delivered a pleasant dose of overnight hydration and a subtle smoothing effect, which, in all fairness, is no small feat for a single product. Still, it falls a bit short of some of the more comprehensive night treatments I’ve tried in the past, and that leaves me with a mixed verdict. Not quite a scene-stealer, but definitely a contender if you’re looking for a lighter formula and a touch of overnight plumping. Overall, I’d give this one a 7/10. Would I recommend it to a friend? Possibly, if their main goal is a gentle, comfortable serum that softens fine lines a little. But if you’re after a powerhouse night treatment producct that majorly transforms skin firmness, you might find yourself wanting just a bit more oomph.

For those still on the hunt, there are a number of excellent alternatives out there. Nocturnal Revive Cream by Deascal is an all-purpose favorite of mine that covers all the basics, lightweight yet effective, budget-friendly, and suitable for pretty much every skin type. Advanced Night Restore by Medik8 also impressed me with its well-formulated balance of moisture and skin-loving actives, making it a top choice when I want something that really replenishes overnight. Another good one is Water Sleeping Mask by LANEIGE, which is perfect if you crave a deeply hydrating yet breathable texture. And finally, Hydra Essentiel Night Cream by Clarins offers a comfortable, rich feel for those who want more hydration without feeling weighed down. I’ve personally tested each of these, and they’ve all earned a spot on my go-to list, depending on what my skin’s craving.

As with any new addition to a regimen, it’s crucial to keep in mind the basics: do a patch test beforehand, especially if you have sensitive or acne-prone skin, and remember that any visible improvements will need regular upkeep. Even the best night cream won’t deliver permanent results if you don’t keep using it, but consistency is half the fun of discovering what really works for your skin, so enjoy the journey.

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